胃がん患者の歯肉縁下病原体評価と歯周病臨床評価-横断的パイロットスタディ

Subgingival Periopathogens Assessment and Clinical Periodontal Evaluation of Gastric Cancer Patients-A Cross Sectional Pilot Study.

抄録

口腔内細菌叢は、消化管癌患者において細菌の多様性が高く、ペリオパソプラズマのレベルも高いことが示されている。最近の研究では、消化管腫瘍組織とリンクし、その進行を加速させるとともに、患者の転帰を悪化させることが示されている。今回のパイロットスタディは、2020年2月から12月にかけて、歯肉縁下プラーク中のいくつかのペリオパターンの豊富さ（、、、）と歯周病状態、胃がんの特徴との関連の可能性を評価するために実施されたものである。本研究は，ルーマニアの Craiova 救急病院第一外科および消化器科の胃癌患者 24 例を対象に実施された．患者の口腔内を検査し，歯肉溝サンプルを採取し，歯周病の兆候を記録した．病理組織学的検査では，腫瘍の分化グレードと大きさを登録した．その結果，調査した周囲病原体から，最も豊富な細菌がすべてのグループで続いていた．本研究では，腫瘍の大きさとすべての歯周病パラメータとの間に強い相関関係が認められたが，腫瘍の大きさと歯周病パラメータとの間にも相関関係が認められ，歯周病，腫瘍の成長およびこのプロセスにおける周囲病原体の関与が示唆された．

Oral microbiota have shown a higher bacterial diversity in patients with cancers of the digestive tract, with higher levels of periopathogens. Recent studies have shown that links to gastro-intestinal neoplastic tissue and accelerates its progression, as well as worsening patient outcome. The present pilot study was carried out between February and December 2020 to evaluate the possible association between the abundance of some periopathogens (, , , and ) in subgingival plaque and periodontal status with characteristics of gastric cancer. The study was performed on a sample of 24 patients with gastric cancer from the 1st Department of Surgery and Department of Gastroenterology within the Clinical County Hospital of Emergency of Craiova, Romania. The patients' oral cavity was examined, gingival crevicular samples were collected, and signs of periodontal disease were recorded. On the histopathological exam, the differentiation grade and size of the tumour were registered. Our results showed that, from the periopathogens studied, the most abundant bacteria were followed by in all groups. In our present study, the strong correlation between tumour dimension and all periodontal parameters but also between tumour dimension and could suggest a positive association between periodontal disease, tumoral growth and periopathogens implication in this process.