胃がんにおけるオキサリプラチン誘発性レルミット徴候

Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer.

• Takeshi Okamoto
• Koichi Takagi
• Katsuyuki Fukuda

抄録

64歳の日本人男性が2週間の胃部不快感を呈した。転移性HER2陽性胃癌と診断された。カペシタビン、オキサリプラチン、トラスツズマブによる化学療法が開始された。第8サイクル目に、突然、首を曲げたときに両足に電気ショックのような痛みを訴えた。オキサリプラチンは中止され、Lhermitte徴候は3ヵ月後に消失した。神経毒性はプラチナ製剤を用いた化学療法では一般的に認められるが、Lhermitte徴候はまれである。オキサリプラチン誘発性のLhermitte徴候が胃癌患者に認められた最初の報告である。

A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neck flexion, consistent with Lhermitte's sign. Oxaliplatin was discontinued, and Lhermitte's sign resolved after 3 months. Neurotoxicity is commonly observed in platinum-based chemotherapy, but Lhermitte's sign is rare. This is the first report of oxaliplatin-induced Lhermitte's sign in a gastric cancer patient.

Copyright © 2020 Takeshi Okamoto et al.