尋常性にきびの治療における血小板豊富な血漿注射とエリスロマイシン2％外用薬の比較

Platelet Rich Plasma Injection versus Topical Erythromycin 2% in Treatment of Acne Vulgaris.

• Zainab A Ibrahim
• Shereen F Gheida
• Amira R El-Halaby
• Ghada F R Hassan
• Dareen A Mohammed

抄録

尋常性にきびは、表皮腺に影響を与える一般的な炎症性の皮膚疾患です。尋常性ざ瘡の治療には様々な治療法がありますが、副作用のない標準的な治療法はありません。血小板リッチ血漿（PRP）は、少量の血漿中に血小板を自己濃縮したものです。血小板が活性化されると、複数の成長因子が放出されます。血小板は血管新生、炎症過程、創傷治癒に重要な役割を果たしている。炎症性にきび病変を有する40人の患者が含まれていた。全患者が2週間ごとに顔面の片側（A群）にPRP注射を6回、もう片側（B群）にエリスロマイシン2％外用を受けた。両群間に有意差があり、A群の方が改善したと報告された（55％の患者が良好から優れた改善を示し、35％の患者が中等度の改善を示し、特に炎症性病変の改善が認められた）。A群はB群に比べて患者の満足度が高く、再発率も低かった。PRPは炎症性ニキビに効果的で安全な治療法であり、特に禁忌とされている場合には他の全身療法に代わる治療法である。

Acne vulgaris is a common inflammatory skin disease that affects the pilosebaceous glands. There are different modalities of treatment of acne but there is no standard treatment free of side effects. Platelet rich plasma (PRP) is an autologous concentration of platelets in a small volume of plasma. When platelets are activated, multiple growth factors are released. They play an important role in angiogenesis, inflammatory process and wound healing. was to evaluate and compare the therapeutic efficacy of platelet rich plasma versus topical erythromycin 2% in treatment of acne vulgaris. 40 patients with inflammatory acne lesions were included. All patients received PRP injection sessions in one side of the face (group A) every 2 weeks for 6 sessions and topical erythromycin 2% in the other side (group B). There was significant difference between both groups in which better improvement was reported in group A (55% of patients showed good to excellent improvement and 35% showed moderate improvement, especially the inflammatory lesions). Group A showed better patients' satisfaction and lower rate of recurrence than group B. PRP is effective and safe treatment option for inflammatory acne and alternative to other systemic modalities especially if they are contraindicated.