喫煙が乾癬に及ぼす影響：爪関与との関連性は？

The effect of smoking on the psoriasis: is it related to nail involvement?

• Selami Aykut Temiz
• İlkay Özer
• Arzu Ataseven
• Recep Dursun
• Mehmet Uyar

抄録

乾癬は、寛解と再発を繰り返し、生活の質に悪影響を及ぼす慢性炎症性皮膚疾患である。喫煙は、動脈硬化性心疾患やメタボリックシンドロームなど、乾癬に伴う合併症の発症を加速させることが知られているが、乾癬の独立した危険因子でもある。本研究では、喫煙と乾癬の関係を調べることを目的とした。研究には、乾癬患者276人と健康なボランティア200人の合計476人が参加した。乾癬患者群では139例（69.5％）、対照群では61例（30.5％）が喫煙していた。乾癬患者は対照群に比べて喫煙が多かった（P＜0.001）。爪乾癬164例中100例（61％）に喫煙が認められ，爪乾癬患者では喫煙が認められた場合の方が有意に多かった（P＜0.001）．喫煙している乾癬患者では全身治療の必要性が高くなることが観察された（P=0,04）。乾癬患者では喫煙が健常者に比べて増加することが知られており，喫煙は乾癬領域重症度指数（PASI）をも増加させます。我々の研究では、文献で初めて喫煙と乾癬爪の病変との間に有意な関係が認められました。さらに、全身治療の必要性は喫煙者の方が高かった。この論文は著作権で保護されています。すべての権利を保有しています。

Psoriasis is a chronic inflammatory skin disease that negatively affects the quality of life with remissions and relapses. Smoking, which is known to accelerate the development of comorbidities that can accompany psoriasis such as atherosclerotic heart disease, metabolic syndrome, is also an independent risk factor for psoriasis. In our study, we aimed to investigate the relationship between smoking and psoriasis. The study included a total of 476 participants with 276 psoriasis patients and 200 healthy volunteers. 139 (69.5%) cases in the psoriasis group and 61 (30.5%) cases in the control group were smoking. Patients with psoriasis had more cigarette smoking than the control group (P < 0.001). Smoking was present in 100 cases (61%) of 164 cases with nail psoriasis and psoriatic nail was significantly more frequently observed in patients with psoriasis when smoking was present (P < 0.001). It was observed that systemic treatment requirements were higher in smoking psoriasis patients (P = 0,04). It is known that cigarette use increases in patients with psoriasis compared to the normal population, and cigarette use also increases the psoriasis area severity index (PASI). In our study, a significant relationship was found between smoking and psoriasis nail involvement first in the literature. Furthermore, the need for systemic treatment was higher in smokers. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.