慢性・侵襲性歯周炎、歯肉炎、歯肉退縮症患者の末梢血中C反応性蛋白質について

C-Reactive Protein in Peripheral Blood of Patients with Chronic and Aggressive Periodontitis, Gingivitis, and Gingival Recessions.

抄録

CRPは炎症に対する急性期反応の指標を反映する血漿タンパク質であり、この反応をモニターする上で選択されるマーカーの一つである。CRP は歯周病の予知や早期発見に利用することができる。本研究では，慢性・侵襲性歯周炎，歯肉炎および歯肉退縮を有する患者の末梢血試料中の全身性 CRP レベルを比較・評価し，歯周病臨床パラメータと比較することを目的とした．全患者（N = 158）を対象に，歯周病治療開始前に検査を実施した．患者は4群に分けられた．A群は侵襲性歯周炎患者26名，B群は慢性歯周炎患者111名，C群は歯肉炎患者13名，D群は歯肉退縮患者8名から構成された．本研究の結果，CRP 値は歯周病の重症度とともに上昇し，両歯周炎患者群，特に侵襲性歯周炎患者では，ポケット深さ指数に比べ，プロービング出血指数と CRP 値に高い正の相関がみられた．

CRP is a plasma protein that reflects a measure of the acute phase response to inflammation and is one of the markers of choice in monitoring this response. CRP can be used for the prediction and early detection of periodontal disease. The aim of this study was to compare and evaluate the systemic levels of CRP in the peripheral blood samples of patients with chronic and aggressive periodontitis, gingivitis, and gingival recessions and compare them with periodontal clinical parameters. All patients (N = 158) were examined prior to the initiation of periodontal treatment. Patients were divided into four groups. Group A consisted of 26 patients with aggressive periodontitis, Group B consisted of 111 patients with chronic periodontitis, Group C consisted of 13 patients with gingivitis, and Group D consisted of 8 patients with gingival recessions. Our study results indicate that CRP levels increase subsequently with the severity of the periodontal disease and that the bleeding on probing index showed much better positive correlation with the CRP levels compared to the pocket depth index in both periodontitis patients groups, especially in aggressive periodontitis patients.