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閉経後の日本人女性における歯周炎と下顎骨喪失と全身の骨の変化との関連
Correlations between periodontitis and loss of mandibular bone in relation to systemic bone changes in postmenopausal Japanese women.
PMID: 16027956 DOI: 10.1007/s00198-005-1955-8.
抄録
軽度から軽度の歯周病を呈する50～69歳の閉経後日本人女性40名を対象に、下顎歯槽骨ミネラル密度（BMD）の新しい測定法を適用した。腰椎BMDは二重X線吸収法（DXA）で、踵骨の音速（SOS）は定量超音波（QUS）で測定した。歯槽骨BMD、踵骨SOS、椎体BMDには加齢に伴う減少が認められた。それぞれの骨量値の間には有意な相関が認められた。歯槽骨BMD、SOS、腰椎BMDを含む骨量データと歯科臨床所見との相関を検討した。歯槽骨BMDと踵骨SOSまたは椎体BMDとの間には有意な相関が認められた。歯槽骨BMDは、歯周ポケットの深さや可動性、踵骨SOSや腰椎BMDと同様に、歯周ポケットの深さや可動性などの歯科臨床所見と有意な相関を示した。多変量解析では、デオキシピリジノリン（DPD）を含む単変量予測因子の組み合わせがアタッチメントレベルを有意に予測した。SOS値は、他の予測因子と組み合わせて愛着レベルを予測するのに有用であった。以上のことから，歯槽骨BMDの新しい評価方法は，歯科臨床所見だけでなく，全身の骨量や強度の予測にも有用であると結論づけられた．
A new method of measuring mandibular alveolar bone mineral density (BMD) was applied to 40 postmenopausal Japanese women aged 50-69 years exhibiting minimal to mild periodontal diseases. Lumbar spine BMD was measured by dual X-ray absorptiometry (DXA) and calcaneus speed of sound (SOS) by quantitative ultrasound (QUS). There were age-related decreases of alveolar BMD, calcaneus SOS and vertebral BMD. There were significant correlations between two of the respective bone mass values. Correlations between clinical dental findings and bone mass data including alveolar BMD, SOS and lumbar spine BMD were investigated. Significant correlations were demonstrated between alveolar BMD and calcaneus SOS or vertebral BMD. Alveolar BMD showed significant correlation with clinical dental findings including periodontal pocket depth and mobility as well as calcaneus SOS and lumbar spine BMD. Using multivariate analysis combinations of univariate predictors, including deoxypyridinoline (DPD), significantly predicted attachment levels. The SOS value was useful combined with other predictors for predicting attachment level. It was concluded that the new method of evaluating alveolar BMD is useful to predict systemic bone mass and strength as well as dental clinical findings.