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コロナウイルス疾患2019の重症度と死亡率の潜在的な予測因子としての血清鉄レベル。A Retrospective Study
Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study.
PMID: 32661499 PMCID: PMC7337740. DOI: 10.1093/ofid/ofaa250.
抄録
背景には以下のようなものがあります。:
様々な肺疾患は鉄欠乏症と関連しています。しかし、コロナウイルス病2019(COVID-19)の鉄の状態に関する情報は乏しい。
Background: Various types of pulmonary diseases are associated with iron deficiency. However, information on iron status in coronavirus disease 2019 (COVID-19) is scarce.
方法:
本研究では,COVID-19 が確認された入院患者 50 例を対象とした.COVID-19の重症度および死亡率の予測における血清鉄の役割を評価した。
Methods: This study included 50 hospitalized patients with confirmed COVID-19. The role of serum iron in predicting severity and mortality of COVID-19 was evaluated.
結果:
本研究のCOVID-19患者で最も多かった症状は、咳(82%)、発熱(64%)、胸部苦痛(42%)であった。50人の患者のうち、45人(90%)の患者は血清鉄値が異常に低かった(<7.8μmol/L)。COVID-19の重症度は、治療前後の血清鉄値と負の相関があり、C反応性蛋白、血清アミロイドA、Dダイマー、乳酸脱水素酵素、尿素窒素、ミオグロビン値と正の相関があった。血清鉄値の低下は,COVID-19 の軽症から重症・重症への移行を予測することができた.重症群で治療後に血清鉄値が低下した患者のうち,7 例(53.8%)が死亡していた.COVID-19生存者と非生存者の間で治療後の血清鉄値に有意な差が認められた。
Results: The most common symptoms of COVID-19 patients in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50 patients, 45 (90%) patients had abnormally low serum iron levels (<7.8 μmol/L). The severity of COVID-19 was negatively correlated with serum iron levels before and after treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. Decreased serum iron level could predict the transition of COVID-19 from mild to severe and critical illness. Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors.
結論:
COVID-19患者では血清鉄欠乏症が検出された。疾患の重症度と死亡率は血清鉄濃度と密接に相関していた。血清鉄濃度の低さはCOVID-19患者の死亡の独立した危険因子であった。
Conclusions: Serum iron deficiency was detected in the patients with COVID-19. The severity and mortality of the disease was closely correlated with serum iron levels. Low serum iron concentration was an independent risk factor for death in COVID-19 patients.
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.